Preoperative Short-course Radiotherapy for Lower Rectal Cancer

Short-course versus long-course neoadjuvant radiotherapy for lower rectal cancer: a systematic review.

OBJECTIVE To analyse the efficacy of short-course (SCRT) versus long-course radiotherapy/chemoradiation (LCRT) as a neoadjuvant modality for the management of lower rectal cancer (LRC). METHODS A systematic review of the literature was undertaken. Selected trials were analysed to generate a summative outcome. RESULTS Seven trials on the efficacy of SCRT versus LCRT as a neoadjuvant modality...

Short-versus Long-course Preoperative Radiotherapy plus Delayed Surgery for Rectal Cancer: a Meta-analysis

Long-course chemo-radiotherapy (45~50 Gy in 25 fractions) with delayed surgery or short-course radiotherapy (25 Gy in 5 fractions) with immediate surgery were the most frequent regimens for the treatment of localized and locally advanced resectable rectal cancer (SWEDISH RECTAL CANCER TRIAL, 1997; Colorectal Cancer Collaborative Group, 2001; Kapiteijn et al., 2001; Sauer et al., 2004). Compared...

Preoperative short-course radiotherapy in rectal cancer patients: results and prognostic factors

Objective The purpose of this study was to evaluate the clinical outcome of preoperative short-course radiotherapy for rectal cancer patients. Methods The study group comprised 210 patients with pathologically proven resectable rectal cancer. Between 2001 and 2013, they were treated preoperatively with short-course radiotherapy (25 Gy delivered in five fractions), followed by total mesorectal...

Preoperative radiotherapy "short course" in rectal cancer in elder patient: low impact on tumor regression

Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer.

BACKGROUND Neoadjuvant chemoradiotherapy does not alter anal sphincter preservation or postoperative complications compared with short-course radiotherapy alone in patients with clinical stage T3 or T4 resectable rectal cancer. The aim of this study was to compare survival, local control and late toxicity in the two treatment groups. METHODS The study randomized 312 patients to receive either...